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Morphologic alterations in the SV, a key structure for producing and maintaining the endocochlear potential (EP), decrease the EP and consequently, affect the cochlear amplification of acoustic signals leading to an increase in auditory thresholds, even in the absence of hair cell death (Gates and Mills, 2005

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Melanotan I also called Melanotan 1 or MT-1 (afamelanotide) is a synthetic analogue of alpha-melanocyte-stimulating hormone (alpha-MSH), studied for its interaction with melanocortin receptors, particularly MC1R, within Australian peptide research

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